A newly released study confirms CBD can help speed up bone healing and strengthen the bone so it may be stronger after healing.
This study was conducted by researchers at Tel Aviv University and Hebrew University and published in The Journal of Bone and Mineral Research.
A bit of explanation: CBD is the acronym for “cannabinoid cannabidiol”, a chemical found in the cannabis plant that has no psychoactive qualities.
Confirmed by this second study, it was found that the skeleton has new bone formation and preventative bone loss built into cannabinoid receptors. Activation of these receptors by the introduction of CBD stimulates strong bone formation.
“The clinical potential of cannabinoid-related compounds is simply undeniable at this point,” said researcher Yankel Gabet about the study. “While there is still a lot of work to be done to develop appropriate therapies, it is clear that it is possible to detach a clinical therapy objective from the psychoactivity of cannabis, CBD, the principal agent in our study, is primarily anti-inflammatory and has no psychoactivity.”
Also confirmed is the use of CBD for broken bones considerably sped up healing of fractures and breaks. How do they know?
Laboratory rats with femur fractures were given pure CBD, no other drug, or CBD with THC, tetrahydrocannabinol, the psychoactive compound in cannabis. It was found that CBD with or without THC, was effective in a speedy and strong repair to the fracture or break.
Further examination reveals that cannabinoids triggers bone formation. As a break develops in the bone, the body builds a bridge of cartilage between the broken bones. That creates a matrix that bone formation can build upon. Also, the repaired bone was discovered to be stronger and thicker at the break than the original bone. This makes the bone stronger than before.
Possible Osteoporosis Remedy?
Osteoporosis occurs when your body disposes of old bone cells without the ability to replace them to keep bones strong. It is suspected that not just CBD is imperative for bone health. Other cannabinoids like cannabigerol, CBG, a non-psychoactive component, is also being examined for its potential treatment for osteoporosis. In fact, GW Pharmaceuticals in Canada has patented CBG for a therapeutic treatment for osteoporosis.
THC is also thought to hold properties that may prevent brittle bones. CB1 receptors, that mainly receive THC molecules are found in bones, the gut and the brain. THC fits in the body’s receptors to help influence biochemical processes in these regions. Without CB1 receptors, the body develops very thick bones but still were victims of osteoporosis. What was happening?
The bones were fatty on the inside rather than healthily filled with bone marrow, a stabilizing and growth component. A 2000 study that used mice demonstrated that CB1 receptors were responsible for the health of associated cells and could be linked to age-related osteoporosis. Mice without CB1 receptors had thick bones but they were filled with fat cells rather than bone marrow producing cells.
Conclusions were drawn that the CB1 receptors regulate the amount of fat and bone marrow and their absence makes it difficult to keep bones healthy. The fatty deposits created a scenario where the bones could not sustain themselves without becoming brittle and easily broken.
Also, CB2 receptors were found to have a connection to bone density by the Hebrew University of Jerusalem. Mice without CB2 receptors had lower bone densities than those who possessed these receptors. A major role of CB2 receptors protects against age-related bone loss and it is important to remember that both CBG and THC interact with CB2 receptors to maintain bone health.
CB2 receptors are found predominantly in the immune system, spleen and liver and in the peripheral nervous system.
Though more research is needed, there is great potential for both CB1 and CB2 receptors to mediate the pain and debilitating brittle bones that accompanies osteoporosis. This translates to use of CBD, CBG and THC in various compound formulas to fight against this disease. The future is bright for the use of medical cannabis in the fight against weak and brittle bones.